Biological Mechanism Profiling Using an Annotated Compound Library
نویسندگان
چکیده
منابع مشابه
Biological mechanism profiling using an annotated compound library.
We present a method for testing many biological mechanisms in cellular assays using an annotated library of 2036 small organic molecules. This annotated compound library represents a large-scale collection of compounds with diverse, experimentally confirmed biological mechanisms and effects. We found that this chemical library is (1) more structurally diverse than conventional, commercially ava...
متن کاملUsing a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors
Mechanistic understanding is crucial to anticancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate-limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis-dependent pathway. To elucidate the mechanism of cell death induced by SPT inhibition, a biologically annotated library of diverse compounds was screen...
متن کاملDesign, synthesis, and biological evaluation of a biyouyanagin compound library.
Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can be merged through total synthesis and molecular design of analogs patterned after the targeted n...
متن کاملDevelopment of an annotated library of neutral human milk oligosaccharides.
Human milk oligosaccharides (HMOs) perform a number of functions including serving as prebiotics to stimulate the growth of beneficial intestinal bacteria, as receptor analogues to inhibit binding of pathogens, and as substances that promote postnatal brain development. There is further evidence that HMOs participate in modulating the human immune system. Because the absorption, catabolism, and...
متن کاملProfiling of Semantically Annotated Proteins
We have exploited semantic annotations of biological entities to develop a novel approach to infer new knowledge. We demonstrate this in four use cases based on the Gene Expression Ontology, an applied ontology that we developed to serve the needs of researchers involved in the analysis of genes and proteins implicated in transcriptional control of pathways/diseases. We have found that semantic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2003
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2003.08.009